Complement Activation and Thrombotic Microangiopathies.


Por: Palomo M, Blasco M, Molina P, Lozano M, Praga M, Torramade-Moix S, Martinez-Sanchez J, Cid J, Escolar G, Carreras E, Paules C, Crispi F, Quintana LF, Poch E, Rodas L, Goma E, Morelle J, Espinosa M, Morales E, Avila A, Cabello V, Ariceta G, Chocron S, Manrique J, Barros X, Martin N, Huerta A, Fraga-Rodriguez GM, Cao M, Martin M, Romera AM, Moreso F, Manonelles A, Gratacós E, Pereira A, Campistol JM and Diaz-Ricart M

Publicada: 6 dic 2019 Ahead of Print: 6 nov 2019
Resumen:
Atypical hemolytic uremic syndrome is a form of thrombotic microangiopathy caused by dysregulation of the alternative complement pathway. There is evidence showing complement activation in other thrombotic microangiopathies. The aim of this study was to evaluate complement activation in different thrombotic microangiopathies and to monitor treatment response.

Filiaciones:
Palomo M:
 Josep Carreras Leukaemia Research Institute

 mpalomo

 Hematopathology, Department of Pathology, Centre de Diagnostic Biomedic (CDB), Hospital Clinic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

 Barcelona Endothelium Team, Barcelona, Spain

Blasco M:
 Department of Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain

 Group of nephro-urological diseases and renal transplantation (IDIBAPS), Barcelona, Spain

Molina P:
 Hematopathology, Department of Pathology, Centre de Diagnostic Biomedic (CDB), Hospital Clinic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

Lozano M:
 Apheresis Unit, Department of Hemotherapy and Hemostasis, Institut Clinic de Malalties Hematologiques i Oncologiques (ICMHO), IDIBAPS, Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain

Praga M:
 Department of Nephrology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain

 Department of Medicine, Universidad Complutense, Madrid, Spain

Torramade-Moix S:
 Hematopathology, Department of Pathology, Centre de Diagnostic Biomedic (CDB), Hospital Clinic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

Martinez-Sanchez J:
 Josep Carreras Leukaemia Research Institute

 Hematopathology, Department of Pathology, Centre de Diagnostic Biomedic (CDB), Hospital Clinic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

 Barcelona Endothelium Team, Barcelona, Spain

Cid J:
 Apheresis Unit, Department of Hemotherapy and Hemostasis, Institut Clinic de Malalties Hematologiques i Oncologiques (ICMHO), IDIBAPS, Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain

Escolar G:
 Hematopathology, Department of Pathology, Centre de Diagnostic Biomedic (CDB), Hospital Clinic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

Carreras E:
 Josep Carreras Leukaemia Research Institute

 Barcelona Endothelium Team, Barcelona, Spain

:
 Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic de Barcelona and Hospital Sant Joan de Deu), ICGON, IDIBAPS, Universitat de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Barcelona, Spain

Crispi F:
 Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic de Barcelona and Hospital Sant Joan de Deu), ICGON, IDIBAPS, Universitat de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Barcelona, Spain

Quintana LF:
 Department of Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain

 Group of nephro-urological diseases and renal transplantation (IDIBAPS), Barcelona, Spain

Poch E:
 Department of Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain

 Group of nephro-urological diseases and renal transplantation (IDIBAPS), Barcelona, Spain

Rodas L:
 Department of Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain

Goma E:
 Department of Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain

Morelle J:
 Division of Nephrology, Cliniques universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

Espinosa M:
 Department of Nephrology, Hospital Universitario Reina Sofía e Instituto Maimonides de Investigaciones Biológicas de Córdoba (IMIBIC), Córdoba, Spain

Morales E:
 Department of Nephrology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain

Avila A:
 Department of Nephrology and Renal Transplantation, Hospital Universitario Dr Peset, Valencia, Spain

Cabello V:
 Department of Nephrology, Hospital Virgen del Rocio, Sevilla, Spain

Ariceta G:
 Department of Pediatric Nephrology, Hospital Materno-Infantil, Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain

Chocron S:
 Department of Pediatric Nephrology, Hospital Materno-Infantil, Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain

Manrique J:
 Department of Nephrology, Complejo Hospitalario de Navarra, Pamplona, Spain

Barros X:
 Department of Nephrology, Hospital Universitari Josep Trueta, Girona, Spain

Martin N:
 Department of Nephrology, Hospital Universitari Josep Trueta, Girona, Spain

Huerta A:
 Department of Nephrology, Hospital Puerta de Hierro Majadahonda, Madrid, Spain

Fraga-Rodriguez GM:
 Department of Pediatric Nephrology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain

Cao M:
 Department of Nephrology, Complejo Hospitalario Universitario A Coruña, Coruña, Spain

Martin M:
 Department of Nephrology, Hospital Universitari Arnau de Vilanova, Lleida, Spain

Romera AM:
 Department of Nephrology, Hospital General Universitario, Ciudad Real, Spain

Moreso F:
 Department of Nephrology, Hospital Universitari Vall d'Hebron, Universitat Autonoma Barcelona, Barcelona, Spain

Manonelles A:
 Kidney Transplant Unit, Department of Nephrology, Hospital de Bellvitge, Universitat de Barcelona, Barcelona, Spain

 and

Gratacós E:
 Fetal i+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic de Barcelona and Hospital Sant Joan de Deu), ICGON, IDIBAPS, Universitat de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Barcelona, Spain

Pereira A:
 CDB, Barcelona, Spain

Campistol JM:
 Department of Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain

Diaz-Ricart M:
 Hematopathology, Department of Pathology, Centre de Diagnostic Biomedic (CDB), Hospital Clinic de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain

 Barcelona Endothelium Team, Barcelona, Spain
ISSN: 15559041





Clinical Journal Of The American Society Of Nephrology
Editorial
American Society of Nephrology, Estados Unidos America
Tipo de documento: Article
Volumen: 14 Número: 12
Páginas: 1719-1732
WOS Id: 000506176900010
ID de PubMed: 31694864
imagen Open Access

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