Transgenerational transmission of small-for-gestational age
Por:
Sepúlveda-Martínez Á, Rodríguez-López M, Paz-Y-Miño F, Casu G, Crovetto F, Gratacós E and Crispi F
Publicada:
1 may 2019
Ahead of Print:
11 sep 2018
Resumen:
Objective To evaluate the transgenerational transmission of small-for-gestational age (SGA).
Methods This was a cohort study of a random sample of 2043 offspring delivered between 1975 and 1993 at Hospital Sant Joan de D ' eu in Barcelona. Exclusion criteria were multiple pregnancy, aneuploidy or genetic syndrome, major birth defects, severe mental disease and macrosomia. Eligible individuals were contacted and those with at least one offspring were included in the study. Participants were classified according to the presence of SGA (defined as birth weight <10th percentile) at birth. Multiple regression analysis was used to determine the presence of SGA or placenta-mediated disease (defined as the presence of SGA, pre-eclampsia, gestational hypertension and/or placental abruption) in the following generation.
Results Of 623 individuals who agreed to participate, 152 (72 born SGA and 80 born appropriatefor-gestational age (AGA)) were reported to have at least one child. Descendants of SGA individuals presented with a lower birth-weight percentile (median, 26 (interquartile range (IQR), 7-52) vs 43 (IQR, 19-75); P < 0.001) and a higher prevalence of SGA (40.3% vs 16.3%; P = 0.001) and placenta-mediated disease (43.1% vs 17.5%; P = 0.001) than did the offspring of AGA individuals. After adjustment for confounding variables, parental SGA background was associated with an almost three-fold increased risk of subsequent SGA or any placenta-mediated disease in the following generation. This association was stronger in SGA mothers than in SGA fathers.
Conclusions Our data provide evidence suggesting a transgenerational transmission of SGA, highlighting the importance of public health strategies for preventing intrauterine growth impairment. Copyright (c) 2018 ISUOG. Published by John Wiley & Sons Ltd.
Filiaciones:
Sepúlveda-Martínez Á:
Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, IDIBAPS, Universitat de Barcelona, CIBER-ER, Barcelona, Spain
Fetal Medicine Unit, Department of Obstetrics and Gynecology Hospital Clínico Universidad de Chile, Santiago de Chile
Rodríguez-López M:
Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, IDIBAPS, Universitat de Barcelona, CIBER-ER, Barcelona, Spain
Pontificia Universidad Javeriana seccional Cali
Paz-Y-Miño F:
Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, IDIBAPS, Universitat de Barcelona, CIBER-ER, Barcelona, Spain
Casu G:
Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, IDIBAPS, Universitat de Barcelona, CIBER-ER, Barcelona, Spain
Crovetto F:
Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, IDIBAPS, Universitat de Barcelona, CIBER-ER, Barcelona, Spain
Gratacós E:
Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, IDIBAPS, Universitat de Barcelona, CIBER-ER, Barcelona, Spain
Crispi F:
Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, IDIBAPS, Universitat de Barcelona, CIBER-ER, Barcelona, Spain
Green Accepted
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