Respiratory microbiota and lower respiratory tract disease
Por:
Lanaspa M, Bassat Q, Medeiros MM and Munoz-Almagro C
Publicada:
1 ene 2017
Ahead of Print:
29 jun 2017
Resumen:
Introduction: The respiratory airways harbor a complex succession of ecological niches with distinct but related bacterial communities. Particular challenges of respiratory microbiome research have led to limited scientific output compared to other human microbiomes.Areas covered: In this review, we summarize the current state of knowledge of the bacterial respiratory microbiome, with a particular focus on associations between the respiratory microbiome and lower respiratory tract conditions.Expert commentary: There is growing evidence that the respiratory microbiome is associated with lower respiratory infectious diseases and related conditions. Most respiratory microbiome reports are metataxonomic cross-sectional or case-control studies with relatively small sample sizes. Large, prospective projects with metatranscriptomics or metabolomics approach are needed to unravel the effect of the respiratory microbiome on health-related conditions. Moreover, standardization in sampling, library preparation, sequencing techniques and data analysis should be encouraged.
Filiaciones:
Lanaspa M:
b ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona , Barcelona , Spain
Bassat Q:
d ICREA , Pg. Lluís Companys 23, 08010 Barcelona , Spain
Medeiros MM:
a Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical , Universidade Nova de Lisboa
Munoz-Almagro C:
g Department of Medicine . Universitat Internacional de Catalunya , Barcelona , Spain
Green Accepted
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